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GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKHC)

ISSN 1865-1038

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Skin transplant in patients with Gorlin-Goltz syndrome as a viable solution for covering skin defects

Poster Plastische Chirurgie

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  • corresponding author Selma Arslanagic - Uniersity Clinical Centre of Sarajevo, Sarajevo, Bosnia
  • Rusmir Arslanagic - Otolaryngology Clinc Clinic Center Sarajevo, Sarajevo, Bosnia and Herzegovina

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2017;13:Doc068

doi: 10.3205/cpo001622, urn:nbn:de:0183-cpo0016226

Published: April 26, 2017

© 2017 Arslanagic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Abstract

Basal cell naevus syndrome is a rare condition which is inherited as an autosomal dominant trait with complete penetrance and variable expressivity. Syndrome is found in all races. Gene responsible has been localized in chromosome 9q22.1-q31, in the PTCH gene,suppressor gene.Men and women are affected equally. The patient described in the following illustrative case is a 41 year old female with basal cell nevus syndrome. The patient was adopted and her family history is unknown. Physical examination: multiple, exulcerate, basal cell carcinoma were evident, multiple palmar and plantar pits, marked bifrontal bossing broadened nasal root, mild hipertelorism, strabismus, exaggerated length of the mandibule, Sprengal deformity, pectus carinatum. Histopathological examination of excised skin tissue: basal cell carcinoma. Surgery is not a option for treatment of Gorlin- Goltz syndrome. Attempts of transplantation of skin in paces of defects failed. Skin was rejected. It is not a therapeutic procedure for treatment of skin defects that develop in disease. They should receive treatment with irradiation, application of isotretionin or acitretin.

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