gms | German Medical Science

Inverted papilloma incidence among newly diagnosed tumors of nose and paranasal sinuses makes from 0,4% to 5%. The case rate makes 0,6 cases per 100000 per year. It is most often diagnosed in male and the male-female ratio makes 5:1. Etiology of the inverted papilloma is unknown, but it is can related to chronic infection of nasal cavity and paranasal sinuses, allergic reactions. The inverted papilloma is a proliferation of the surface epithelium and its invagination in the underlying tissues. This tumor usually develops on the lateral wall of the nose in the area of the middle nasal passage and often invades maxillary and ethmoid sinuses. The tumor is benign, but having an aggressive growth, it invades surrounding tissues. The tumor can grow for a long time without any symptoms. Being located in a sinus it can lead to development of recurrent sinusites. Differential diagnosis of the inverted papilloma should be made between nasal polyps, benign and malignant neoplasms. Besides routine examination it is necessary to carry out nasal endoscopic examination, computer tomography of paranasal sinuses and to take samples for histological analysis. Treatment of the inverted papillomas is only surgical. Primary goal of the treatment is maximum possible excision of the pathological tissue. There are several variants of various open and endoscopic approaches. According to the literature the recurrence rate for the papillomas makes about 3-19%, malignization is observed in 5% of cases. At the clinic of the Pavlov First Saint Petersburg State Medical University during the period from 2013 till 2016 we have performed 14 surgeries in patients with inverted papilloma. All the patients have undergone complete otorhinolaryngological examination, nasal endoscopy and computer tomography.

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