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73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

29.05. - 01.06.2022, Köln

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The mechanical response of gliomas and peritumoral white matter under mechanical preconditioning

Die mechanische Reaktion von Gliomen und peritumoraler weißer Substanz unter mechanischer Vorbehandlung

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  • presenting/speaker Abraham Tsitlakidis - KAT Attica General Hospital, Department of Neurosurgery, Kifisia, Griechenland; AHEPA University Hospital, Aristotle University of Thessaloniki, First Department of Neurosurgery, Thessaloniki, Griechenland
  • Aristeidis Kritis - School of Medicine, Aristotle University of Thessaloniki, Laboratory of Physiology, Thessaloniki, Griechenland
  • Anastasia S. Tsingotjidou - School of Veterinary Medicine, Aristotle University of Thessaloniki, Laboratory of Anatomy, Histology and Embryology, Thessaloniki, Griechenland
  • Angeliki Cheva - School of Medicine, Aristotle University of Thessaloniki, Department of Pathology, Thessaloniki, Griechenland
  • Ioannis Patsalas - AHEPA University Hospital, Aristotle University of Thessaloniki, First Department of Neurosurgery, Thessaloniki, Griechenland
  • Nicholas Foroglou - AHEPA University Hospital, Aristotle University of Thessaloniki, First Department of Neurosurgery, Thessaloniki, Griechenland

Deutsche Gesellschaft für Neurochirurgie. 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie. Köln, 29.05.-01.06.2022. Düsseldorf: German Medical Science GMS Publishing House; 2022. DocJ-HSNC04

doi: 10.3205/22dgnc443, urn:nbn:de:0183-22dgnc4439

Published: May 25, 2022

© 2022 Tsitlakidis et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Glioma mechanics play a key role in the progression and invasion of gliomas. The present study investigated the influence of mechanical preconditioning on glioma and peritumoral white matter elasticity.

Methods: Fourteen patients with a hemispheric diffuse glioma participated in the study. Fresh tissue specimens were acquired during craniotomy from the resected gliomas and the adjacent white matter. The specimens, after being sliced with an appropriate vibratome, underwent repetitive deformation using atomic force microscope (AFM) nanoindentation for the determination of the elastic modulus. The impact of mechanical preconditioning on glioma and peritumoral white matter elasticity was estimated with linear mixed-effects models.

Results: Both the glioma and the white matter tissue initially presented stiffening and subsequently showed softening. The elastic modulus of the white matter returned to its initial condition, whereas in the glioma tissue the stiffening was reversed only in part.

Conclusion: The two type of tissue examined show differences in their mechanical behavior, worthy of further investigation. Further nanoindentation studies on glioma mechanics should take into consideration the impact of preconditioning on measurement accuracy.