Article
Spatio-temporal resolution of stereo-EEG signals following olfactory stimulation
Zeitliche und räumliche Auflösung der SEEG Signale nach der Stimulation mittels olfaktorischer Stimulation
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Published: | May 25, 2022 |
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Outline
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Objective: Dynamics of olfactory processing and the role of neural oscillations have received little attention in humans. We report intracranial recordings of temporo-spatial oscillations using stereo-electroencephalography (SEEG) following olfactory stimulation.
Methods: One patient (34 yrs.) with medical resistant epilepsy was monitored by SEEG. Peach and fish odor were presented in 2 sessions separated by 5 days. Using MatLab based software we analyzed odor-induced changes in theta, beta, and gamma frequency bands from bilateral recordings from amygdala, hippocampus, temporo-occipital regions, temporo-medial gyrus and parahippocampal gyrus.
Results: There were similar odor-induced oscillation patterns in both sessions in the left Hippocampus, left parahippocampal gyrus, left temporooccipital lobe and predominantly right hippocampus and parahippocampal gyrus. However, in the second session, oscillations were weaker for repeated stimuli, a mechanism known as long-term central adaptation. The high frequency bilateral oscillations in amygdala, parahippocampus and hippocampus suggested higher-level, cognition-related processing of olfactory information.
Conclusion: We report an investigation of the human olfactory network characterized by typical spatio-temporal patterns of neuronal oscillations. The identified characteristic oscillatory response to odors is consistent by the sparse literature. The results are expected to promote the development of implants that can electrically induce olfactory perceptions in patients without a sense of smell.
Funding: This research received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 964529