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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Early postoperative depression in patients with newly diagnosed glioblastoma

Früh-postoperative Depressionen bei Patienten mit Glioblastom

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  • presenting/speaker Daniela Pierscianek - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Marvin Darkwah Oppong - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Anna Michel - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Laurèl Rauschenbach - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Yahya Ahmadipour - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Mehdi Chihi - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Karsten Henning Wrede - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Ulrich Sure - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland
  • Ramazan Jabbarli - Universitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocP071

doi: 10.3205/21dgnc359, urn:nbn:de:0183-21dgnc3590

Published: June 4, 2021

© 2021 Pierscianek et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Depressive disorders are common in patients with cancer, frequently influencing the disease course. Although the overall survival (OS) of glioblastoma (GBM) has improved under multimodal therapies, the prognosis remains generally poor. This study aimed to assess the occurrence, risk factors and clinical impact of early depression in patients with GBM.

Methods: Medical records of patients with newly diagnosed GBM between 2008 and 2018 were analyzed regarding demographic, clinical, molecular characteristics and outcome (overall survival [OS]) was assessed. Patients with perioperative depressive disorders that needed medical treatment were considered as patients with early postoperative depression (EPD). Univariate and multivariate analysis were carried out. Patients with pre-existent history of depression (n=7) and pediatric cases (n=5) were excluded from further analysis.

Results: Of 710 patients in the final analysis, 118 patients (16.6%) were diagnosed with EPD. In univariate analysis, sex, body mass index, arterial hypertension, diabetes, midline tumor location, allocation to the stereotactic biopsy and postoperative KPS were associated with EPD. Multivariate analysis confirmed an independent association of the female sex (aOR=1.82 p=0.005), age (aOR=0.98 per-year-increase, p=0.044), arterial hypertension (aOR=1.84, p=0.018) and midline tumor location (aOR=2.07, p=0.033) with the occurrence of EPD. Cox regression analysis showed that EPD was associated with a shorter OS (aHR=1.23, p=0.05) independently of common survival predictors of GBM (age, preoperative KPS, extent of resection, IDH1 mutation, and MGMT methylation status).

Conclusion: EPD is a frequent event in GBM and is associated with demographic characteristics (female sex and younger age), comorbidity (arterial hypertension) and tumor location (affecting midline structures). Since EPD is independently associated with poor OS, there is a crucial need to screen GBM patients for depressive symptoms to offer adequate psycho-oncological care during postoperative treatment.