Article
Is there an impact of total nimodipine dosage on postoperative hearing preservation/cranial nerve function after vestibular schwannoma resection? A retrospective analysis of a randomised, multicentre trial
Gibt es einen Zusammenhang zwischen der Gesamtmenge an verabreichtem Nimodipin und dem Erhalt der Funktionen der Hör- und Fazialisnerven nach der Resektion von Vestibularis-Schwannomen? Eine retrospektive Analyse einer randomisierten und multizentrischen Studie
Search Medline for
Authors
Published: | June 4, 2021 |
---|
Outline
Text
Objective: This study aims to evaluate the relationship of total nimodipine dosage, tumor size, hearing and facial nerve preservation in vestibular schwannoma surgery.
Methods: In a retrospective analysis the data of 93 patients out of 112 patients of a randomized, multicenter trial that investigated the efficacy of prophylactic nimodipine treatment in vestibular schwannoma surgery were examined. Logistic regression analysis was applied in order to observe the correlation between total nimodipine dosage and postoperative hearing preservation and facial nerve function with respect to tumor size.
Results: Logistic regression analysis showed significant correlation of total nimodipine dosage and postoperative hearing preservation (p=0.049), tumor size (p=0.023) as well as their interaction with postoperative hearing preservation (p=0.043). Comparable analysis of postoperative function of the facial nerve did not correlate significantly with the total nimodipine dosage.
Conclusion: It can be proposed that a higher total nimodipine dosage and a lower tumor size describe better chances for postoperative hearing preservation. Moreover, the positive effect on the preservation of hearing due to higher total nimodipine dosage can especially be seen/ is especially relevant in patients with bigger tumor sizes.