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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Dorsal root ganglion stimulation (DRGS) relieves chronic neuropathic pain along with a decrease in cortical gamma power

Dorsalganglienstimulation (DRGS) reduziert chronische neuropathische Schmerzen unter gleichzeitiger Abnahme der kortikalen Gammabandaktivität

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  • presenting/speaker Matthias Morgalla - Universität Tübingen, Neurochirurgische Klinik, Tübingen, Deutschland
  • Yi Zhang - Universität Tübingen, Neurochirurgische Klinik, Tübingen, Deutschland
  • Marcos Tatagiba - Universität Tübingen, Neurochirurgische Klinik, Tübingen, Deutschland
  • Bankim Chander - Universität Tübingen, Neurochirurgische Klinik, Tübingen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV063

doi: 10.3205/21dgnc064, urn:nbn:de:0183-21dgnc0640

Published: June 4, 2021

© 2021 Morgalla et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Gamma band oscillations reflect ongoing pain intensity in chronic pain patients. It was or hypothesis that dorsal root ganglion stimulation (DRGS) relieves chronic neuropathic pain along with a decrease in the broadband cortical gamma power.

Methods: We examined 9 patients (2 females, mean age 56.8 years; range 36 to 77 years) who were diagnosed with CNP and received DRGS therapy. We used the numeric rating scale (NRS) on the painful limb and simultaneously recorded electroencephalography (EEG) to measure broad-band gamma power. Measurements were taken on day 1 and 7.

Results: The resting state gamma power after DRGS revealed a significant decrease (p = .012) in the low gamma power between 30 – 45 Hz, recorded from the central electrodes from day 1 (M = 0.48, SD = 0.24) to day 7 (M = 0.31, SD = 0.12). High gamma-band power (55-95Hz) recorded from the frontal electrodes also decreased (p = .047) significantly from day 1 (M = 0.40, SD = 0.29) to day 7 (M = 0.23, SD = 0.11). We found a positive correlation between the low (rs = 0.528, p = .024) and high (rs = 0.292, p = .24) gamma power with CNP rating.

Conclusion: A decrease in the broadband gamma power may be considered as further evidence in favor of a reduction of the hyperexcitability of the nociceptive system in response to DRGS therapy. This is another important neurophysiological proof of the efficacy of DRGS.

Figure 1 [Fig. 1], Figure 2 [Fig. 2]