Article
The German national TBI-registry – preliminary data from the pilot period
Das deutsche Schädel-Hirn-Trauma Register – erste Daten aus der Pilotphase
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Authors
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Alexander Younsi
- Universitätsklinikum Heidelberg, Neurochirurgie, Heidelberg, Deutschland
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Andreas W. Unterberg
- Universitätsklinikum Heidelberg, Neurochirurgie, Heidelberg, Deutschland
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Patrick Czorlich
- Universitätsklinikum Hamburg-Eppendorf, Neurochirurgie, Hamburg, Deutschland
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Aldin Hamou Hussam
- Universitätsklinikum RWTH Aachen, Neurochirurgie, Aachen, Deutschland
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Dirk Lindner
- Universitätsklinikum Leipzig, Neurochirurgie, Leipzig, Deutschland
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Michael Luchtmann
- Universitätslinikum Magdeburg, Neurochirurgie, Magdeburg, Deutschland
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Thomas Lustenberger
- Universitätsklinikum Frankfurt am Main, Unfallchirurgie, Frankfurt am Main, Deutschland
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Marc Maegele
- Kliniken der Stadt Köln, Unfallchirurgie, Köln, Deutschland
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Ingo Marzi
- Universitätsklinikum Frankfurt am Main, Unfallchirurgie, Frankfurt am Main, Deutschland
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Uwe Max Mauer
- Bundeswehrkrankenhaus Ulm, Neurochirurgie, Ulm, Deutschland
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Kirsten Schmieder
- Universitätsklinikum der Ruhr-Universität Bochum, Neurochirurgie, Bochum, Deutschland
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Martin Strowitzki
- Berufsgenossenschaftliche Unfallklinik Murnau, Neurochirurgie, Murnau, Deutschland
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Eberhard Uhl
- Universitätsklinikum Gießen und Marburg, Neurochirurgie, Gießen, Deutschland
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Thomas Westermaier
- Universitätsklinikum Würzburg, Neurochirurgie, Würzburg, Deutschland
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Stefan Wolf
- Charité – Universitätsmedizin Berlin, Neurochirurgie, Berlin, Deutschland
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Wolf-Ingo Steudel
- Universitätsklinikum Homburg, Neurochirurgie, Homburg, Deutschland
| Published: | June 26, 2020 |
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Outline
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Objective: Since nationwide data on the epidemiology, treatment characteristics and long-term outcome of severe traumatic brain injury (TBI) in Germany are lacking, neurosurgeons from the German Neurosurgery Society (DGNC) and traumatologists from the German Trauma Society (DGU) joined forces in 2016 to conceptualize a TBI module for the well-established Trauma Register of the DGU (TR-DGU), functioning as the German National TBI registry (GNTR). After funding for this endeavor was secured, the corresponding electronic case report forms were designed, ethical approval was obtained, and a one-year-long pilot period of the GNTR was initiated in February 2019.
Methods: Preliminary data from the pilot period of the GNTR which has been initiated in February 2019 and will continue until February 2020, aiming to enroll severe TBI patients in 22 neurosurgical as well as traumatological departments across Germany is presented. In the GNTR, TBI patients are prospectively enrolled when treatment on the ICU ≥ 24h is indicated. A variety of clinical and radiological parameters are collected, and the outcome is assessed by the GOSE score at discharge as well as at 6- and 12 months follow-up.
Results: Details on the structure and data set of the GNTR as well as associated milestones and pitfalls during the conception and implementation phase are outlined. Demographic as well as clinical, laboratory and radiological characteristics of the TBI patients enrolled during the pilot period of the GNTR are presented, indicating the current epidemiology and care situation of severe TBI in Germany. In addition, mortality, as well as early functional outcome following severe TBI in Germany measured by the GOSE score, are described. If available, factors associated with an unfavorable outcome (GOSE 1-4) after severe TBI are assessed using uni- and multivariate regression analyses.
Conclusion: National TBI registries are needed to collect high quality, prospective data on the most severe form of this devastating condition. The preliminary results from the pilot period of the GNTR do not only depict the epidemiology of severe TBI in Germany but also allow to evaluate and compare factors associated with its long-term outcome, ultimately helping to improve its treatment.
