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43. Kongress der Deutschen Gesellschaft für Rheumatologie, 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie, 25. Wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie

02.-05. September 2015, Bremen

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Endothelial Progenitor Cells and vascular stiffness in Psoriasis vulgaris and Psoriasis arthritis

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  • Natalina Sugiarto - Universitätsmedizin Göttingen, Klinik für Nephrologie und Rheumatologie, Göttingen
  • Daniel Patschan - Universitätsklinikum Göttingen, Nephrologie und Rheumatologie, Göttingen
  • Elvira Henze - Universitätsklinikum Göttingen, Nephrologie und Rheumatologie, Göttingen
  • Gerhard A. Müller - Klinik für Nephrologie und Rheumatologie Universitätsmedizin Göttingen, Göttingen
  • Susann Patschan - Universitätsklinikum Göttingen, Nephrologie und Rheumatologie, Göttingen

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Gesellschaft für Kinder- und Jugendrheumatologie. 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR). Bremen, 02.-05.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocER.25

doi: 10.3205/15dgrh079, urn:nbn:de:0183-15dgrh0797

Published: September 1, 2015

© 2015 Sugiarto et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

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Introduction: Psoriasis (Ps) may be complicated by disease-associated joint inflammation (Psoriasis arthritis – PsA) in up to 40%. PsA is characterized by neo-formation of bone and connective tissue in close proximity to affected joints. Patients with both, Ps and PsA have been reported to display higher cardiovascular risks (CVR) as oposed to healthy subjects. Endothelial Progenitor Cells (EPCs) are critically involved in vascular repair and reduced EPC numbers / competence have been associated with increased CVR. Aim of the study was to analyze the EPC system and vascular stiffness in Ps and PsA.

Methods: Twenty-seven PsA and 18 Ps patients were included into the study, 22 healthy subjects served as controls. EPC regeneration was evaluated by a colony-forming assay, peripheral EPC numbers were enumerated by cytometric analysis (CD133+/KDR+ cells). Vascular stiffness was quantified by tonometric analysis of Pulse Wave Velocity (PWV) and the vascular Augmentation Index (AIX).

Results: None of the analyzed parameters (EPC colony numbers, percentages of CD133+/KDR+ cells, PWV, and vascular AIX) differed between controls and patients with Ps and PsA. In addition, differences between Ps and PsA were also not significant.

Conclusion: Although Ps and PsA have been reported to coincide with higher CVR, indirect CVR parameters are not deteriorated. Thus, indirect procedures for CVR assessement may not be useful in certain types of autoimmune-mediated diseases such as Ps and PsA.