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60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

German Society for Neuropathology and Neuroanatomy

26. - 28.08.2015, Berlin

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Ex vivo activation of naturally occurring IL-17-producing T cells does not require IL-6

Meeting Abstract

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  • corresponding author presenting/speaker Harald Hofstetter - HHU Düsseldorf, Neurologie, Düsseldorf, Germany
  • Vsevolod Smolianov - HHU Düsseldorf, Neurologie, Düsseldorf, Germany
  • Thomas Dehmel - HHU Düsseldorf, Neurologie, Düsseldorf, Germany
  • Bernd C. Kieseier - HHU Düsseldorf, Neurologie, Düsseldorf, Germany
  • Hans Peter Hartung - HHU Düsseldorf, Neurologie, Düsseldorf, Germany

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Berlin, 26.-28.08.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15dgnnP28

doi: 10.3205/15dgnn52, urn:nbn:de:0183-15dgnn525

Published: August 25, 2015

© 2015 Hofstetter et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Interleukin (IL-)17 is a potent proinflammatory cytokine for which an important role in the immune response against infections and in autoimmune diseases has been demonstrated. Recently, it has been shown that - in addition to mature T cells which are primed in the immune periphery - this cytokine can also be produced by T cells in the thymus, so-called naturally occurring IL-17-producing T cells (nT17 cells). In this study we demonstrate that the generation and activation of nT17 cells in the thymus do not depend on the cytokine IL-6. In addition, nT17 cells are not regulated by IL-2. These properties of nT17 cells significantly differ from induced IL-17-producing T cells primed in the immune periphery (iT17 cells). Given the strong association of IL-17-producing T cells with immune responses against infections and human autoimmune diseases, closer characterization of nT17 cells is warranted.