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64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

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Long-term follow-up of cortical language sites by navigated transcranial magnetic stimulation compared to repeated awake craniotomy

Meeting Abstract

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  • Sandro M. Krieg - Neurochirurgische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
  • Nico Sollmann - Neurochirurgische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
  • Theresa Hauck - Neurochirurgische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
  • Bernhard Meyer - Neurochirurgische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
  • Florian Ringel - Neurochirurgische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocDI.05.02

doi: 10.3205/13dgnc195, urn:nbn:de:0183-13dgnc1955

Published: May 21, 2013

© 2013 Krieg et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Repetitive navigated transcranial magnetic stimulation (rTMS) is increasingly used for mapping of human language areas. In order to increase its clinical impact, the evaluation of cortical plasticity in terms of language function seems to be a key application.

Method: Three patients with left-sided opercular glioblastoma multiforme (GBM) underwent rTMS language mapping and language mapping by awake surgery for resection of the initial and 7–11 months later for recurrent GBM. Results of rTMS and intraoperative mapping were compared using the cortical parcellation system (CPS).

Results: Left-sided language dominance and induction of clear speech errors were provoked during rTMS and during awake surgery. Consistency of the results of both methods was present in all cases and the plastic changes over time were present in one case.

Conclusions: This small series shows for the first time that language plasticity can be revealed by preoperative rTMS with an object naming task, even in recurrent gliomas.