Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils

Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR (2008)
Journal of Negative Results in BioMedicine 7(1): 2.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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URN
urn:nbn:de:0070-pub-17837616
Autor*in
Brummelte, Susanne; Grund, Thorsten; Moll, Gunther H.; Teuchert-Noodt, GertraudUniBi; Dawirs, Ralph R.
Einrichtung
Fakultät für Biologie
Abstract / Bemerkung
It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and handling have a positive effect on the dopaminergic fiber density in the prefrontal cortex (PFC) of early traumatized gerbils (Meriones unguiculatus). The current study was performed to investigate if enriched environment during MP application has an additional influence on the dopaminergic and GABAergic fiber densities in the PFC and amygdala in this animal model. Animals received a single early dose of methamphetamine (MA; 50 mg/kg; i.p.) on postnatal day (PD) 14, which is known to cause multiple changes in the subsequent development of several neurotransmitter systems including the dopaminergic systems, and were then treated with oral daily applications of MP (5 mg/kg) from PD30–60. Animals treated this way were either transferred to an enriched environment after weaning (on PD30) or were kept under impoverished rearing conditions. There was no effect of an enriched environment on the dopaminergic or GABAergic fiber density neither in the PFC nor in the amygdala. With regard to former studies these results underline the particular impact of MP in the treatment of ADHD.
Erscheinungsjahr
2008
Zeitschriftentitel
Journal of Negative Results in BioMedicine
Band
7
Ausgabe
1
Art.-Nr.
2
ISSN
1477-5751
Page URI
https://pub.uni-bielefeld.de/record/1783761

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Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 2008;7(1): 2.
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., & Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1), 2. https://doi.org/10.1186/1477-5751-7-2
Brummelte, Susanne, Grund, Thorsten, Moll, Gunther H., Teuchert-Noodt, Gertraud, and Dawirs, Ralph R. 2008. “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”. Journal of Negative Results in BioMedicine 7 (1): 2.
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., and Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine 7:2.
Brummelte, S., et al., 2008. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1): 2.
S. Brummelte, et al., “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”, Journal of Negative Results in BioMedicine, vol. 7, 2008, : 2.
Brummelte, S., Grund, T., Moll, G.H., Teuchert-Noodt, G., Dawirs, R.R.: Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 7, : 2 (2008).
Brummelte, Susanne, Grund, Thorsten, Moll, Gunther H., Teuchert-Noodt, Gertraud, and Dawirs, Ralph R. “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”. Journal of Negative Results in BioMedicine 7.1 (2008): 2.
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3 Zitationen in Europe PMC

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Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
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