BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.

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Serval ID
serval:BIB_FD7EEF16556C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Journal
Journal of Experimental Medicine
Author(s)
Thompson J.S., Schneider P., Kalled S.L., Wang L., Lefevre E.A., Cachero T.G., MacKay F., Bixler S.A., Zafari M., Liu Z.Y., Woodcock S.A., Qian F., Batten M., Madry C., Richard Y., Benjamin C.D., Browning J.L., Tsapis A., Tschopp J., Ambrose C.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
2000
Volume
192
Number
1
Pages
129-135
Language
english
Abstract
The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.
Keywords
Animals, B-Cell Activating Factor, B-Cell Maturation Antigen, B-Lymphocytes/immunology, Cell Line, Cell Survival, Homeostasis, Humans, Immunoglobulin G/immunology, Immunoglobulin kappa-Chains/genetics, Immunoglobulin kappa-Chains/immunology, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred BALB C, Palatine Tonsil/immunology, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/immunology, Recombinant Proteins/immunology, Spleen/immunology, Transfection, Tumor Necrosis Factor-alpha
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:19
Last modification date
20/08/2019 16:28
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