TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.

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Version: Final published version
Serval ID
serval:BIB_EF177791C6D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
Journal
Journal of Experimental Medicine
Author(s)
Pappu B.P., Borodovsky A., Zheng T.S., Yang X., Wu P., Dong X., Weng S., Browning B., Scott M.L., Ma L., Su L., Tian Q., Schneider P., Flavell R.A., Dong C., Burkly L.C.
ISSN
1540-9538
Publication state
Published
Issued date
05/2008
Peer-reviewed
Oui
Volume
205
Number
5
Pages
1049-1062
Language
english
Abstract
T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not well understood. We show that the expression of a tumor necrosis factor receptor family member, death receptor 3 (DR3; also known as TNFRSF25), is selectively elevated in Th17 cells, and that TL1A, its cognate ligand, can promote the proliferation of effector Th17 cells. To further investigate the role of the TL1A-DR3 pathway in Th17 regulation, we generated a TL1A-deficient mouse and found that TL1A(-/-) dendritic cells exhibited a reduced capacity in supporting Th17 differentiation and proliferation. Consistent with these data, TL1A(-/-) animals displayed decreased clinical severity in experimental autoimmune encephalomyelitis (EAE). Finally, we demonstrated that during EAE disease progression, TL1A was required for the optimal differentiation as well as effector function of Th17 cells. These observations thus establish an important role of the TL1A-DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease.
Keywords
Animals, Autoimmune Diseases, Brain, Cell Differentiation, Cell Division, Cytokines, DNA Primers, Encephalomyelitis, Autoimmune, Experimental, Female, HLA-DR3 Antigen, Mice, Mice, Inbred C57BL, Mice, Knockout, Spinal Cord, T-Lymphocytes, T-Lymphocytes, Regulatory, Tumor Necrosis Factor Ligand Superfamily Member 15
Pubmed
Web of science
Open Access
Yes
Create date
13/02/2009 19:19
Last modification date
20/08/2019 16:16
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