Atypical hematological manifestation of celiac disease: A case report of aplastic anemia in a 2-year-old child and review of the literature.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_ED565C60A734
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Atypical hematological manifestation of celiac disease: A case report of aplastic anemia in a 2-year-old child and review of the literature.
Journal
Pediatric investigation
Author(s)
von Graffenried T., Rizzi M., Russo M., Nydegger A., Kayemba-Kay's S.
ISSN
2574-2272 (Electronic)
ISSN-L
2574-2272
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
5
Number
2
Pages
159-162
Language
english
Notes
Publication types: Case Reports
Publication Status: epublish
Abstract
Celiac disease typically presents with symptoms of malabsorption, but extraintestinal manifestations are increasingly reported. Aplastic anemia as the mode of celiac disease presentation is extremely rare in children.
We report a 2-year-old boy who presented with loose stools, loss of appetite, and bicytopenia with severe aregenerative normocytic anemia. Investigations, including bone marrow aspirate and biopsy, revealed aplastic anemia. Screening for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies. A duodenal biopsy confirmed the histologic features of celiac disease. The child received a packed red cell transfusion and was started on a gluten-free diet, with a very good prognosis and normalization of both his blood and histological parameters. To the best of our knowledge, our report is the sixth pediatric case in the literature.
Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.
Keywords
Aplastic anemia, Celiac disease, Child, Gluten‐free diet
Pubmed
Open Access
Yes
Create date
06/07/2021 10:36
Last modification date
12/01/2022 7:14
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