Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_E9BE158D6FA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.
Journal
Scientific reports
Author(s)
Castagné R., Kelly-Irving M., Campanella G., Guida F., Krogh V., Palli D., Panico S., Sacerdote C., Tumino R., Kleinjans J., de Kok T., Kyrtopoulos S.A., Lang T., Stringhini S., Vermeulen R., Vineis P., Delpierre C., Chadeau-Hyam M.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
09/12/2016
Peer-reviewed
Oui
Volume
6
Pages
38705
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Consistent evidence is accumulating to link lower socioeconomic position (SEP) and poorer health, and the inflammatory system stands out as a potential pathway through which socioeconomic environment is biologically embedded. Using bloodderived genome-wide transcriptional profiles from 268 Italian participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we evaluated the association between early life, young and later adulthood SEP and the expression of 845 genes involved in human inflammatory responses. These were examined individually and jointly using several inflammatory scores. Our results consistently show that participants whose father had a manual (as compared to nonmanual) occupation exhibit, later in life, a higher inflammatory score, hence indicating an overall increased level of expression for the selected inflammatory-related genes. Adopting a life course approach, these associations remained statistically significant upon adjustment for later-in-life socioeconomic experiences. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated, and were replicated in an independent study. Our study provides additional evidence that childhood SEP is associated with a sustainable upregulation of the inflammatory transcriptome, independently of subsequent socioeconomic experiences. Our results support the hypothesis that early social inequalities impacts adult physiology.
Keywords
Adult, Biomarkers/metabolism, Female, Gene Expression Profiling, Genome-Wide Association Study, Humans, Inflammation/genetics, Inflammation/metabolism, Male, Middle Aged, Socioeconomic Factors, Transcriptome
Pubmed
Web of science
Open Access
Yes
Create date
22/12/2016 12:36
Last modification date
20/08/2019 16:12
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