Intermittent atrial tachycardia facilitates atrial fibrillation by a shortening of activation recovery interval

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Version: Final published version
Serval ID
serval:BIB_E814A6406FA9
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Intermittent atrial tachycardia facilitates atrial fibrillation by a shortening of activation recovery interval
Title of the conference
ESC Congress
Author(s)
Tenkorang J. N., Jousset F., Ruchat P., Vesin J. -M., Pascale P., Fromer M., Schaefer S. C., Narayan S. M., Pruvot E.
Address
Stockholm, Sweden, August 28-September 01, 2010
ISBN
0195-668X
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
31
Series
European Heart Journal
Pages
116-116
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Introduction: We recently observed in a chronic ovine model that a shortening of action potential duration (APD) as assessed by the activation recovery interval (ARI) may be a mechanism whereby pacing-induced atrial tachycardia (PIAT) facilitates atrial fibrillation (AF), mediated by a return to 1:1 atrial capture after the effective refractory period has been reached. The aim of the present study is to evaluate the effect of long term intermittent burst pacing on ARI before induction of AF.Methods: We specifically developed a chronic ovine model of PIAT using two pacemakers (PM) each with a right atrial (RA) lead separated by ∼2cm. The 1st PM (Vitatron T70) was used to record a broadband unipolar RA EGM (800 Hz, 0.4 Hz high pass filter). The 2nd was used to deliver PIAT during electrophysiological protocols at decremental pacing CL (400 beats, from 400 to 110ms) and long term intermittent RA burst pacing to promote electrical remodeling (5s of burst followed by 2s of sinus rhythm) until onset of sustained AF. ARI was defined as the time difference between the peak of the atrial repolarization wave and the first atrial depolarization. The mean ARIs of paired sequences (before and after remodeling), each consisting of 20 beats were compared.Results: As shown in the figure, ARIs (n=4 sheep, 46 recordings) decreased post remodeling compared to baseline (86±19 vs 103±12 ms, p<0.05). There was no difference in atrial structure as assessed by light microscopy between control and remodeled sheep.Conclusions: Using standard pacemaker technology, atrial ARIs as a surrogate of APDs were successfully measured in vivo during the electrical remodeling process leading to AF. The facilitation of AF by PIAT mimicking salvos from pulmonary veins is heralded by a significant shortening of ARI.
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13/04/2011 9:36
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20/08/2019 16:10
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