Saliva cotinine concentrations in pregnant women who smoke and use nicotine patches.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E6D9C7E1309B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Saliva cotinine concentrations in pregnant women who smoke and use nicotine patches.
Journal
Addiction
Author(s)
Claire R., Coleman T., Leonardi-Bee J., Berlin I.
ISSN
1360-0443 (Electronic)
ISSN-L
0965-2140
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
114
Number
9
Pages
1651-1658
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Due to concerns about increased exposure to nicotine, pregnant women using nicotine replacement therapy (NRT) to stop smoking are usually advised to stop using NRT if they relapse to smoking. This study investigated whether this is justified. We compared changes in saliva cotinine from baseline to 2 weeks post-target quit date pregnant smokers who relapsed to smoking and continued to use their patches having been assigned to use nicotine patches or placebo.
Controlled pre-post design stratified by intervention condition from the 'Study of Nicotine Patch in Pregnancy', a randomized, placebo-controlled trial.
A sample of 268 pregnant women, assigned placebo (n = 122) or nicotine (n = 146) patches, who returned for further supplies of patches and who reported any smoking in the week prior to a visit at 2 weeks after their target quit date.
Saliva cotinine concentrations were measured at baseline and 2 weeks after participants' target quit dates. Any smoking in the previous week was assessed by self-report, validated by expired air carbon monoxide (CO).
There was no change in saliva cotinine concentrations between baseline and 2 weeks post-target quit date in saliva cotinine concentration in the nicotine patch group [ratio of geometric means = 0.94, 95% confidence interval (CI) = 0.83 to 1.07; P = 0.37, Bayes factor = 0.15]. However, there was a reduction in reported number of cigarettes smoked/day (mean difference -6, 95% CIs -7 to -5, P < 0.001) and in CO concentrations (mean difference -3.0 parts per million, 95% CIs -4.2 to -1.9, P < 0.001). These changes were not significantly different from changes in the placebo group except for cigarette consumption, which reduced more in the nicotine group (P = 0.046).
In women trying to stop smoking with the aid of a nicotine patch but having smoked at 2 weeks post-target quit, their nicotine concentration did not change from baseline, but they reported smoking fewer cigarettes and had lower carbon monoxide concentrations.
Keywords
Cotinine, nicotine, nicotine replacement therapy, pregnancy, smoking, smoking cessation
Pubmed
Web of science
Open Access
Yes
Create date
25/05/2019 10:59
Last modification date
15/01/2021 7:12
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