Differential contributions of subthalamic beta rhythms and 1/f broadband activity to motor symptoms in Parkinson's disease.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_DF70028CA20A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differential contributions of subthalamic beta rhythms and 1/f broadband activity to motor symptoms in Parkinson's disease.
Journal
NPJ Parkinson's disease
Author(s)
Martin S., Iturrate I., Chavarriaga R., Leeb R., Sobolewski A., Li A.M., Zaldivar J., Peciu-Florianu I., Pralong E., Castro-Jiménez M., Benninger D., Vingerhoets F., Knight R.T., Bloch J., Millán JDR
ISSN
2373-8057 (Print)
ISSN-L
2373-8057
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
4
Pages
32
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Excessive beta oscillatory activity in the subthalamic nucleus (STN) is linked to Parkinson's Disease (PD) motor symptoms. However, previous works have been inconsistent regarding the functional role of beta activity in untreated Parkinsonian states, questioning such role. We hypothesized that this inconsistency is due to the influence of electrophysiological broadband activity -a neurophysiological indicator of synaptic excitation/inhibition ratio- that could confound measurements of beta activity in STN recordings. Here we propose a data-driven, automatic and individualized mathematical model that disentangles beta activity and 1/f broadband activity in the STN power spectrum, and investigate the link between these individual components and motor symptoms in thirteen Parkinsonian patients. We show, using both modeled and actual data, how beta oscillatory activity significantly correlates with motor symptoms (bradykinesia and rigidity) only when broadband activity is not considered in the biomarker estimations, providing solid evidence that oscillatory beta activity does correlate with motor symptoms in untreated PD states as well as the significant impact of broadband activity. These findings emphasize the importance of data-driven models and the identification of better biomarkers for characterizing symptom severity and closed-loop applications.
Pubmed
Web of science
Open Access
Yes
Create date
20/11/2018 8:41
Last modification date
30/04/2021 6:15
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