Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D66CA0261E74
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies.
Journal
Medical physics
Author(s)
Gonçalves Jorge P., Grilj V., Bourhis J., Vozenin M.C., Germond J.F., Bochud F., Bailat C., Moeckli R.
ISSN
2473-4209 (Electronic)
ISSN-L
0094-2405
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
49
Number
3
Pages
1831-1838
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools compatible with CONV and UHDR irradiations for preclinical FLASH studies.
Two BCTs were used to measure the output of the Oriatron eRT6 linac. First, the correspondence between the set nominal beam parameters and those measured by the BCTs was checked. Then, we established the relationship between the total exit charge (measured by BCTs) and the absorbed dose to water. The influence of the pulse width (PW) and the pulse repetition frequency (PRF) at UHDR was characterized, as well as the short- and long-term stabilities of the relationship between the exit charge and the dose at CONV and UHDR.
The BCTs were able to determine consistently the number of pulses, PW, and PRF. For fixed PW and pulse height, the exit charge measured from BCTs was correlated with the dose, and linear relationships were found with uncertainties of 0.5 % and 3 % in CONV and UHDR mode, respectively. Short- and long-term stabilities of the dose-to-charge ratio were below 1.6 %.
We implemented commercially available BCTs and demonstrated their ability to act as online beam monitoring systems to support FLASH preclinical studies with CONV and UHDR irradiations. The implemented BCTs support dosimetric measurements, highlight variations among multiple measurements in a row, enable monitoring of the physics parameters used for irradiation, and are an important step for the safety of the clinical translation of FLASH radiation therapy.
Keywords
Electrons, Particle Accelerators, Phantoms, Imaging, Radiometry, Radiotherapy Dosage, FLASH, beam current transformer, charge, dosimetry, monitoring, ultrahigh dose rate
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2022 10:47
Last modification date
13/08/2022 6:14
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