Analysis of OXA-204 carbapenemase-producing <i>Enterobacteriaceae</i> reveals possible endoscopy-associated transmission, France, 2012 to 2014.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D6531FA7F131
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analysis of OXA-204 carbapenemase-producing <i>Enterobacteriaceae</i> reveals possible endoscopy-associated transmission, France, 2012 to 2014.
Journal
Euro surveillance
Author(s)
Potron A., Bernabeu S., Cuzon G., Pontiès V., Blanchard H., Seringe E., Naas T., Nordmann P., Dortet L.
ISSN
1560-7917 (Electronic)
ISSN-L
1025-496X
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
22
Number
49
Pages
NA
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing <i>Enterobacteriaceae</i> in Europe, involving 12 isolates of an ST90 <i>Escherichia coli</i> clone and nine isolates of an ST147 <i>Klebsiella pneumoniae</i> clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The <i>bla</i> <sub>OXA-204</sub> gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.

Keywords
Anti-Bacterial Agents/therapeutic use, Endoscopes/microbiology, Enterobacteriaceae/enzymology, Enterobacteriaceae/genetics, Enterobacteriaceae/isolation & purification, Enterobacteriaceae Infections/epidemiology, Enterobacteriaceae Infections/microbiology, France/epidemiology, Humans, Multilocus Sequence Typing, Plasmids/genetics, Polymerase Chain Reaction, beta-Lactamases/genetics, beta-Lactamases/secretion, OXA-48-like, antibiotic resistance, carbapenems, endoscope, nosocomial, outbreak
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2017 17:16
Last modification date
20/08/2019 15:56
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