Circadian regulation of renal function and potential role in hypertension.

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Ressource 1Download: BIB_D33E7C4F56F6.P001.pdf (293.82 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_D33E7C4F56F6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circadian regulation of renal function and potential role in hypertension.
Journal
Current Opinion In Nephrology and Hypertension
Author(s)
Bonny O., Firsov D.
ISSN
1473-6543 (Electronic)
ISSN-L
1062-4821
Publication state
Published
Issued date
2013
Volume
22
Number
4
Pages
439-444
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublishDocument Type: Review
Abstract
PURPOSE OF REVIEW: Previous studies have shown that a variety of specific renal functions exhibit circadian oscillations. This review aims to provide an update on the molecular mechanisms underlying circadian rhythms in the kidney, and to discuss how dysregulation of circadian rhythms can interfere with kidney function.
RECENT FINDINGS: The molecular mechanism responsible for generating and maintaining circadian rhythms has been unraveled in great detail. This mechanism, known as the circadian clock, drives circadian oscillation in expression levels of a large number of renal mRNA transcripts. Several proteins critically involved in renal homeostatic functions have been shown to exhibit significant circadian oscillation in their expression levels or in their posttranslational modifications. In transgenic mouse models, disruption of circadian clock activity results in dramatic changes in the circadian pattern of urinary sodium and potassium excretion and causes significant changes in arterial blood pressure. A growing amount of evidence suggests that dysregulation of circadian rhythms is associated with the development of hypertension and accelerated progression of chronic kidney disease and cardiovascular disease in humans. Chronotherapy studies have shown that the efficacy of antihypertensive medication is greatly dependent on the circadian time of drug administration.
SUMMARY: Recent research points to the major role of circadian rhythms in renal function and in control of blood pressure.
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2013 17:00
Last modification date
20/10/2020 10:08
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