Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

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Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_CC64990CDC5B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.
Journal
The Journal of cell biology
Author(s)
French L.E., Hahne M., Viard I., Radlgruber G., Zanone R., Becker K., Müller C., Tschopp J.
ISSN
0021-9525
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
133
Number
2
Pages
335-43
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two major cytolytic pathways mediated by CD8+ cytolytic T cells. To gain further understanding of the Fas system., we have analyzed Fas and FasL expression during mouse development and in adult tissues. In developing mouse embryos, from 16.5 d onwards, Fas mRNA is detectable in distinct cell types of the developing sinus, thymus, lung, and liver, whereas FasL expression is restricted to submaxillary gland epithelial cells and the developing nervous system. Significant Fas and FasL expression were observed in several nonlymphoid cell types during embryogenesis, and generally Fas and FasL expression were not localized to characteristic sites of programmed cell death. In the adult mouse, RNase protection analysis revealed very wide expression of both Fas and FasL. Several tissues, including the thymus, lung, spleen, small intestine, large intestine, seminal vesicle, prostate, and uterus, clearly coexpress the two genes. Most tissues constitutively coexpressing Fas and FasL in the adult mouse are characterized by apoptotic cell turnover, and many of those expressing FasL are known to be immune privileged. It may be, therefore, that the Fas system is implicated in both the regulation of physiological cell turnover and the protection of particular tissues against potential lymphocyte-mediated damage.
Keywords
Animals, Antigens, CD95, Apoptosis, Base Sequence, Embryonic and Fetal Development, Fas Ligand Protein, Female, Gene Expression Regulation, Developmental, Male, Membrane Glycoproteins, Mice, Molecular Sequence Data, Organ Specificity, RNA, Messenger, Testis
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 15:47
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