Late onset tacrolimus-induced life-threatening polyneuropathy in a kidney transplant recipient patient

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State: Public
Version: Final published version
Serval ID
serval:BIB_C909A46141DC
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Late onset tacrolimus-induced life-threatening polyneuropathy in a kidney transplant recipient patient
Journal
Clinical Kidney Journal
Author(s)
Renard D., Gauthier T., Venetz J.-P., Buclin T., Kuntzer T.
ISSN
2048-8505 (Print)
2048-8513 (Electronic)
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
5
Number
4
Pages
323-326
Language
english
Notes
clinical report
Abstract
A 59-year-old kidney recipient was diagnosed with a late onset of severe chronic inflammatory demyelinating polyradiculoneuropathy and almost fully recovered after stopping tacrolimus and one course of intravenous immunoglobulin treatment. Unique features of this patient are the unusually long time lapse between initiation of tacrolimus and the adverse effect (10 years), a strong causality link and several arguments pointing toward an inflammatory etiology. When facing new neurological signs and symptoms in graft recipients, it is important to bear in mind the possibility of a drug-induced adverse event. Discontinuation of the suspect drug and immunomodulation are useful treatment options.
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19/01/2013 15:14
Last modification date
20/08/2019 15:44
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