A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.

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Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_C5C84B9FE984
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.
Journal
Journal of Experimental Medicine
Author(s)
Jongeneel C.V., Acha-Orbea H., Blankenstein T.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
1990
Volume
171
Number
6
Pages
2141-2146
Language
english
Abstract
We have amplified a (CA)n:(GT)n microsatellite from the TNF promoters of a panel of mouse strains using the polymerase chain reaction. The length of the microsatellites was polymorphic, with eight alleles observed among 15 inbred strains bearing seven distinct H-2 haplotypes, and four outbred strains. In B10 congenic strains, the TNF allele detected by microsatellite polymorphism segregated with the MHC, and in recombinant haplotypes (NOD, NZW), it segregated with H-2D. The TNF allele found in the NZW strain (H-2z) was distinct from those of all other haplotypes, consistent with the hypothesis that this strain may carry a genetic defect in TNF production.
Keywords
Alleles, Animals, Base Sequence, DNA/genetics, DNA, Satellite/genetics, Genetic Markers, Haplotypes, Liver/cytology, Mice, Mice, Inbred Strains, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Genetic/genetics, Promoter Regions, Genetic/genetics, Species Specificity, Tumor Necrosis Factor-alpha/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:39
Last modification date
20/08/2019 15:41
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