Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects.

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serval:BIB_C246B1D82C2D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects.
Journal
Diabetes Care
Author(s)
Couchepin C.,  K.A., Bortolotti M., da Encarnaçao J.A., Oboni J.B., Tran C., Schneiter P., Tappy L.
ISSN
1935-5548[electronic]
Publication state
Published
Issued date
2008
Volume
31
Number
6
Pages
1254-1256
Language
english
Abstract
OBJECTIVE: To compare the metabolic effects of fructose in healthy male and female subjects. RESEARCH DESIGN AND METHODS: Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding. RESULTS: Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects. CONCLUSIONS: Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.
Keywords
Adult, Body Mass Index, Energy Intake, Fasting, Female, Fructose, Humans, Insulin, Male, Reference Values, Sex Characteristics, Triglycerides
Pubmed
Web of science
Open Access
Yes
Create date
23/10/2008 8:03
Last modification date
20/08/2019 15:37
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