Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans.

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Version: Final published version
Serval ID
serval:BIB_C2352A0D8CCA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans.
Journal
Genomics Data
Author(s)
Fuertes Marraco S.A., Soneson C., Delorenzi M., Speiser D.E.
ISSN
2213-5960 (Electronic)
ISSN-L
2213-5960
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
5
Pages
297-301
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
The live-attenuated Yellow Fever (YF) vaccine YF-17D induces a broad and polyfunctional CD8 T cell response in humans. Recently, we identified a population of stem cell-like memory CD8 T cells induced by YF-17D that persists at stable frequency for at least 25 years after vaccination. The YF-17D is thus a model system of human CD8 T cell biology that furthermore allows to track and study long-lasting and antigen-specific human memory CD8 T cells. Here, we describe in detail the sample characteristics and preparation of a microarray dataset acquired for genome-wide gene expression profiling of long-lasting YF-specific stem cell-like memory CD8 T cells, compared to the reference CD8 T cell differentiation subsets from total CD8 T cells. We also describe the quality controls, annotations and exploratory analyses of the dataset. The microarray data is available from the Gene Expression Omnibus (GEO) public repository with accession number GSE65804.
Pubmed
Open Access
Yes
Create date
21/06/2016 19:28
Last modification date
20/08/2019 15:37
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