The neuroanatomical model of post-stroke depression: towards a change of focus?

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Serval ID
serval:BIB_C10843BC694D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The neuroanatomical model of post-stroke depression: towards a change of focus?
Journal
Journal of the neurological sciences
Author(s)
Santos M., Kövari E., Gold G., Bozikas V.P., Hof P.R., Bouras C., Giannakopoulos P.
ISSN
1878-5883[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
283
Number
1-2
Pages
158-62
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
One third of all stroke survivors develop post-stroke depression (PSD). Depressive symptoms adversely affect rehabilitation and significantly increase risk of death in the post-stroke period. One of the theoretical views on the determinants of PSD focuses on psychosocial factors like disability and social support. Others emphasize biologic mechanisms such as disruption of biogenic amine neurotransmission and release of proinflammatory cytokines. The "lesion location" perspective attempts to establish a relationship between localization of stroke and occurrence of depression, but empirical results remain contradictory. These divergences are partly related to the fact that neuroimaging methods, unlike neuropathology, are not able to assess precisely the full extent of stroke-affected areas and do not specify the different types of vascular lesions. We provide here an overview of the known phenomenological profile and current pathogenic hypotheses of PSD and present neuropathological data challenging the classic "single-stroke"-based neuroanatomical model of PSD. We suggest that vascular burden due to the chronic accumulation of small macrovascular and microvascular lesions may be a crucial determinant of the development and evolution of PSD.
Pubmed
Web of science
Create date
23/07/2009 15:19
Last modification date
20/08/2019 15:35
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