Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter.

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Version: Final published version
Serval ID
serval:BIB_BF166DA79107
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter.
Journal
Journal of Psychiatry and Neuroscience : Jpn
Author(s)
Ruef A., Curtis L., Moy G., Bessero S., Badan Bâ M., Lazeyras F., Lövblad K.O., Haller S., Malafosse A., Giannakopoulos P., Merlo M.
ISSN
1488-2434 (Electronic)
ISSN-L
1180-4882
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
37
Number
5
Pages
305-312
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Background: Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. Methods: We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. Results: We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. Limitations: The modest sample size and the absence of women in our series could limit the impact of our results. Conclusion: Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis.
Pubmed
Web of science
Open Access
Yes
Create date
24/09/2012 13:44
Last modification date
20/08/2019 15:33
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