A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies

Details

Ressource 1Download: BIB_BDF23F3F7BCB.P001.pdf (728.33 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_BDF23F3F7BCB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies
Journal
Annals of Occupational Hygiene
Author(s)
Berthet Aurélie, Heredia-Ortiz Roberto, Vernez David, Danuser Brigitta, Bouchard Michèle
ISSN
1475-3162 (Electronic)
ISSN-L
0003-4878
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
56
Number
7
Pages
815-828
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
Captan and folpet are two fungicides largely used in agriculture, but biomonitoring data are mostly limited to measurements of captan metabolite concentrations in spot urine samples of workers, which complicate interpretation of results in terms of internal dose estimation, daily variations according to tasks performed, and most plausible routes of exposure. This study aimed at performing repeated biological measurements of exposure to captan and folpet in field workers (i) to better assess internal dose along with main routes-of-entry according to tasks and (ii) to establish most appropriate sampling and analysis strategies. The detailed urinary excretion time courses of specific and non-specific biomarkers of exposure to captan and folpet were established in tree farmers (n = 2) and grape growers (n = 3) over a typical workweek (seven consecutive days), including spraying and harvest activities. The impact of the expression of urinary measurements [excretion rate values adjusted or not for creatinine or cumulative amounts over given time periods (8, 12, and 24 h)] was evaluated. Absorbed doses and main routes-of-entry were then estimated from the 24-h cumulative urinary amounts through the use of a kinetic model. The time courses showed that exposure levels were higher during spraying than harvest activities. Model simulations also suggest a limited absorption in the studied workers and an exposure mostly through the dermal route. It further pointed out the advantage of expressing biomarker values in terms of body weight-adjusted amounts in repeated 24-h urine collections as compared to concentrations or excretion rates in spot samples, without the necessity for creatinine corrections.
Keywords
Captan, Fungicides, Industrial, Phthalimides, Environmental Monitoring/methods, Occupational Exposure/analysis, Agriculture,
Pubmed
Web of science
Create date
26/04/2012 9:01
Last modification date
20/08/2019 15:32
Usage data