Adaptations of Natural Killer Cells to Self-MHC Class I.

Details

Ressource 1Download: BIB_BB450D1901CE.P001.pdf (502.15 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_BB450D1901CE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adaptations of Natural Killer Cells to Self-MHC Class I.
Journal
Frontiers in Immunology
Author(s)
Bessoles S., Grandclément C., Alari-Pahissa E., Gehrig J., Jeevan-Raj B., Held W.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
5
Pages
349
Language
english
Notes
Publication types: Journal Article Publication Status: epublish, pdf:Focused Review ARTICLE
Abstract
Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptation occurs during NK cell development, but recent findings show that mature NK cells can also adapt to the presence or absence of MHC class I molecules. Here, we summarize how NK cells adjust to changes in the expression of MHC class I molecules. We propose an extension of existing models, in which MHC class I recognition during NK cell development sequentially instructs and maintains NK cell function. The elucidation of the molecular basis of the two effects may identify ways to improve the fitness of NK cells and to prevent the loss of NK cell function due to persistent alterations in their environment.
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2015 8:59
Last modification date
20/08/2019 15:29
Usage data