Caspase-3 and RasGAP: a stress-sensing survival/demise switch.

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Ressource 1Download: 5_24007977_Postprint.pdf (854.98 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B1DB48B11C04
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Caspase-3 and RasGAP: a stress-sensing survival/demise switch.
Journal
Trends In Cell Biology
Author(s)
Khalil H., Bertrand M.J., Vandenabeele P., Widmann C.
ISSN
1879-3088 (Electronic)
ISSN-L
0962-8924
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
24
Number
2
Pages
83-89
Language
english
Notes
Publication types: Journal Article ; Document Type: Review, pdf : Opinion
Abstract
The final decision on cell fate, survival versus cell death, relies on complex and tightly regulated checkpoint mechanisms. The caspase-3 protease is a predominant player in the execution of apoptosis. However, recent progress has shown that this protease paradoxically can also protect cells from death. Here, we discuss the underappreciated, protective, and prosurvival role of caspase-3 and detail the evidence showing that caspase-3, through differential processing of p120 Ras GTPase-activating protein (RasGAP), can modulate a given set of proteins to generate, depending on the intensity of the input signals, opposite outcomes (survival vs death).
Pubmed
Web of science
Create date
21/04/2014 15:49
Last modification date
20/08/2019 15:20
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