Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis.

Details

Ressource 1Download: BIB_AE519D3630ED.P001.pdf (1236.65 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_AE519D3630ED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk of All-Cause Mortality in Alcohol-Dependent Individuals: A Systematic Literature Review and Meta-Analysis.
Journal
Ebiomedicine
Author(s)
Laramée P., Leonard S., Buchanan-Hughes A., Warnakula S., Daeppen J.B., Rehm J.
ISSN
2352-3964 (Electronic)
ISSN-L
2352-3964
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2
Number
10
Pages
1394-1404
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
BACKGROUND: Alcohol dependence (AD) carries a high mortality burden, which may be mitigated by reduced alcohol consumption. We conducted a systematic literature review and meta-analysis investigating the risk of all-cause mortality in alcohol-dependent subjects.
METHODS: MEDLINE, MEDLINE In-Process, Embase and PsycINFO were searched from database conception through 26th June 2014. Eligible studies reported all-cause mortality in both alcohol-dependent subjects and a comparator population of interest. Two individuals independently reviewed studies. Of 4540 records identified, 39 observational studies were included in meta-analyses.
FINDINGS: We identified a significant increase in mortality for alcohol-dependent subjects compared with the general population (27 studies; relative risk [RR] = 3.45; 95% CI [2.96, 4.02]; p < 0.0001). The mortality increase was also significant compared to subjects qualifying for a diagnosis of alcohol abuse or subjects without alcohol use disorders (AUDs). Alcohol-dependent subjects continuing to drink heavily had significantly greater mortality than alcohol-dependent subjects who reduced alcohol intake, even if abstainers were excluded (p < 0.05).
INTERPRETATION: AD was found to significantly increase an individual's risk of all-cause mortality. While abstinence in alcohol-dependent subjects led to greater mortality reduction than non-abstinence, this study suggests that alcohol-dependent subjects can significantly reduce their mortality risk by reducing alcohol consumption.
Keywords
Alcohol-Related Disorders/epidemiology, Alcohol-Related Disorders/mortality, Alcoholism/epidemiology, Alcoholism/mortality, Cause of Death, Humans, Odds Ratio, Risk
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2016 13:15
Last modification date
20/08/2019 15:18
Usage data