The past, present and future of renin-angiotensin aldosterone system inhibition.

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State: Public
Version: author
Serval ID
serval:BIB_ACED76EDC886
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The past, present and future of renin-angiotensin aldosterone system inhibition.
Journal
International Journal of Cardiology
Author(s)
Mentz R.J., Bakris G.L., Waeber B., McMurray J.J., Gheorghiade M., Ruilope L.M., Maggioni A.P., Swedberg K., Pina I.L., Fiuzat M., O'Connor C.M., Zannad F., Pitt B.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
167
Number
5
Pages
1677-1687
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Abstract
The renin-angiotensin aldosterone system (RAAS) is central to the pathogenesis of cardiovascular disease. RAAS inhibition can reduce blood pressure, prevent target organ damage in hypertension and diabetes, and improve outcomes in patients with heart failure and/or myocardial infarction. This review presents the history of RAAS inhibition including a summary of key heart failure, myocardial infarction, hypertension and atrial fibrillation trials. Recent developments in RAAS inhibition are discussed including implementation and optimization of current drug therapies. Finally, ongoing clinical trials, opportunities for future trials and issues related to the barriers and approvability of novel RAAS inhibitors are highlighted.
Pubmed
Web of science
Open Access
Yes
Create date
20/09/2013 17:09
Last modification date
20/08/2019 15:16
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