Diffusion Spectrum Imaging after stroke shows structural changes in the contra-lateral motor network correlating with functional recovery
Details
State: Public
Version: author
Serval ID
serval:BIB_AB3EE8C29132
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Diffusion Spectrum Imaging after stroke shows structural changes in the contra-lateral motor network correlating with functional recovery
Title of the conference
ISMRM 2011, 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine
Address
Montreal, Quebec, Canada, May 7-13, 2011
ISBN
1524-6965
Publication state
Published
Issued date
2011
Volume
19
Series
Proceedings of the International Society for Magnetic Resonance in Medicine
Pages
4199
Language
english
Abstract
There is growing interest in understanding the role of
the non-injured contra-lateral hemisphere in stroke
recovery. In the experimental field, histological
evidence has been reported that structural changes occur
in the contra-lateral connectivity and circuits during
stroke recovery. In humans, some recent imaging studies
indicated that contra-lateral sub-cortical pathways and
functional and structural cortical networks are
remodeling, after stroke. Structural changes in the
contra-lateral networks, however, have never been
correlated to clinical recovery in patients. To determine
the importance of the contra-lateral structural changes
in post-stroke recovery, we selected a population of
patients with motor deficits after stroke affecting the
motor cortex and/or sub-cortical motor white matter. We
explored i) the presence of Generalized Fractional
Anisotropy (GFA) changes indicating structural
alterations in the motor network of patientsâeuro?
contra-lateral hemisphere as well as their longitudinal
evolution ii) the correlation of GFA changes with
patientsâeuro? clinical scores, stroke size and demographics
data iii) and a predictive model.
the non-injured contra-lateral hemisphere in stroke
recovery. In the experimental field, histological
evidence has been reported that structural changes occur
in the contra-lateral connectivity and circuits during
stroke recovery. In humans, some recent imaging studies
indicated that contra-lateral sub-cortical pathways and
functional and structural cortical networks are
remodeling, after stroke. Structural changes in the
contra-lateral networks, however, have never been
correlated to clinical recovery in patients. To determine
the importance of the contra-lateral structural changes
in post-stroke recovery, we selected a population of
patients with motor deficits after stroke affecting the
motor cortex and/or sub-cortical motor white matter. We
explored i) the presence of Generalized Fractional
Anisotropy (GFA) changes indicating structural
alterations in the motor network of patientsâeuro?
contra-lateral hemisphere as well as their longitudinal
evolution ii) the correlation of GFA changes with
patientsâeuro? clinical scores, stroke size and demographics
data iii) and a predictive model.
Keywords
Diffusion MRI, Stroke, Plasticity, CIBM-AIT
Create date
07/01/2014 9:11
Last modification date
20/08/2019 16:15
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