Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_AA82CE3BA2B8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants.
Journal
Nutrients
Author(s)
Austin S., De Castro C.A., Sprenger N., Binia A., Affolter M., Garcia-Rodenas C.L., Beauport L., Tolsa J.F., Fischer Fumeaux C.J.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
05/06/2019
Peer-reviewed
Oui
Volume
11
Number
6
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3'-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact.
Keywords
2′-fucosyllactose (2′FL), 3′-sialyllactose (3′SL), Lewis, disialyllacto-N-tetraose (DSLNT), human milk oligosaccharides (HMO), lactation, milk group, preterm, secretor
Pubmed
Open Access
Yes
Create date
30/06/2019 15:29
Last modification date
13/10/2019 6:08
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