Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma

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Version: author
Serval ID
serval:BIB_A4DCA0AC9D4C
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma
Journal
Case Reports in Dermatology
Author(s)
Kuonen F., Bucher M., de Leval L., Vernez M., Gilliet M., Conrad C., Feldmeyer L.
ISSN
1662-6567 (Electronic)
ISSN-L
1662-6567
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
6
Number
1
Pages
37-42
Language
english
Notes
Publication types: Journal Article Publication Status: epublish, pdf : We describe a case
Abstract
BACKGROUND: Hepatosplenic T cell lymphoma (HSTL) is a rare but very aggressive peripheral T cell lymphoma whose initial silent clinical presentation unfortunately delays the diagnosis and worsens the prognosis of patient survival. Efforts should be aimed at early recognition and treatment. METHODS: We describe a case of a 62-year-old woman who presented at our clinic with a non-palpable purpuric eruption of the face. Investigations revealed thrombocytopenia with hepatosplenomegaly, which showed rapid progression together with accentuation of the purpura. Two months later, a bone marrow biopsy revealed the diagnosis of a HSTL. RESULTS: The patient received six cycles of CHOP chemotherapy (vincristine, cyclophosphamide, doxorubicin, methylprednisolone) followed by a well-tolerated autologous bone marrow graft. Normalization of the platelet count resulted in regression of the purpuric rash. CONCLUSION: To our knowledge, this is the first report of a facial thrombocytopenic purpura as the inaugural symptom of HSTL. It emphasizes the privileged position of the dermatologist for early recognition of potentially lethal HSTL.
Pubmed
Open Access
Yes
Create date
08/04/2014 14:35
Last modification date
20/08/2019 15:10
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