The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.

Details

Ressource 1Download: 214. DelPozo et al.pdf (17377.91 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A41FC1BA53F1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.
Journal
Disease models & mechanisms
Author(s)
Del-Pozo J., Headon D.J., Glover J.D., Azar A., Schuepbach-Mallepell S., Bhutta M.F., Riddell J., Maxwell S., Milne E., Schneider P., Cheeseman M.
ISSN
1754-8411 (Electronic)
ISSN-L
1754-8403
Publication state
Published
Issued date
01/03/2022
Peer-reviewed
Oui
Volume
15
Number
3
Pages
dmm049034
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In mice, rats, dogs and humans, the growth and function of sebaceous glands and eyelid Meibomian glands depend on the ectodysplasin signalling pathway. Mutation of genes encoding the ligand EDA, its transmembrane receptor EDAR and the intracellular signal transducer EDARADD leads to hypohidrotic ectodermal dysplasia, characterised by impaired development of teeth and hair, as well as cutaneous glands. The rodent ear canal has a large auditory sebaceous gland, the Zymbal's gland, the function of which in the health of the ear canal has not been determined. We report that EDA-deficient mice, EDAR-deficient mice and EDARADD-deficient rats have Zymbal's gland hypoplasia. EdaTa mice have 25% prevalence of otitis externa at postnatal day 21 and treatment with agonist anti-EDAR antibodies rescues Zymbal's glands. The aetiopathogenesis of otitis externa involves infection with Gram-positive cocci, and dosing pregnant and lactating EdaTa females and pups with enrofloxacin reduces the prevalence of otitis externa. We infer that the deficit of sebum is the principal factor in predisposition to bacterial infection, and the EdaTa mouse is a potentially useful microbial challenge model for human acute otitis externa.
Keywords
Animals, Ear Canal, Ectodermal Dysplasia 1, Anhidrotic, Ectodysplasins, Female, Lactation, Mice, Otitis Externa, EDAR, EDARADD, FBXO11, Hypohidrotic ectodermal dysplasia, MECOM, Sparse and wavy hair rat, Tabby mouse
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 176256
Create date
08/02/2022 8:26
Last modification date
20/07/2022 6:12
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