Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A24A5D715550
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.
Journal
Mucosal immunology
Author(s)
Trompette A., Pernot J., Perdijk O., Alqahtani RAA, Domingo J.S., Camacho-Muñoz D., Wong N.C., Kendall A.C., Wiederkehr A., Nicod L.P., Nicolaou A., von Garnier C., Ubags NDJ, Marsland B.J.
ISSN
1935-3456 (Electronic)
ISSN-L
1933-0219
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
15
Number
5
Pages
908-926
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for example, food allergies and asthma. Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, we report that a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components. Our results demonstrate that dietary fibre and SCFA improve epidermal barrier integrity, ultimately limiting early allergen sensitization and disease development.The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com ).
Keywords
Allergens, Child, Dermatitis, Atopic, Dietary Fiber, Fatty Acids, Volatile, Food Hypersensitivity, Humans, Keratinocytes
Pubmed
Web of science
Open Access
Yes
Create date
17/06/2022 16:34
Last modification date
23/11/2022 7:13
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