The circadian clock coordinates ribosome biogenesis.

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Version: author
Serval ID
serval:BIB_9CEF4402C7E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The circadian clock coordinates ribosome biogenesis.
Journal
Plos Biology
Author(s)
Jouffe C., Cretenet G., Symul L., Martin E., Atger F., Naef F., Gachon F.
ISSN
1545-7885 (Electronic)
ISSN-L
1544-9173
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
11
Number
1
Pages
e1001455
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2013 18:31
Last modification date
20/10/2020 10:08
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