Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_9566E917E0B3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells.
Journal
Development
Author(s)
Madsen S., Ramosaj M., Knobloch M.
ISSN
1477-9129 (Electronic)
ISSN-L
0950-1991
Publication state
Published
Issued date
15/05/2021
Peer-reviewed
Oui
Volume
148
Number
10
Pages
dev191924
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Cellular metabolism has recently emerged as a key regulator of stem cell behavior. Various studies have suggested that metabolic regulatory mechanisms are conserved in different stem cell niches, suggesting a common level of stem cell regulation across tissues. Although the balance between glycolysis and oxidative phosphorylation has been shown to be distinct in stem cells and their differentiated progeny, much less is known about lipid metabolism in stem cell regulation. In this Review, we focus on how stem cells are affected by two major lipid metabolic pathways: the build-up of lipids, called de novo lipogenesis, and the breakdown of lipids, called fatty acid beta-oxidation. We cover the recent literature on hematopoietic stem cells, intestinal stem cells, neural stem/progenitor cells and cancer stem cells, where these two lipid pathways have been studied in more depth.
Keywords
Animals, Energy Metabolism/physiology, Fatty Acids/metabolism, Glycolysis/physiology, Hematopoiesis/physiology, Hematopoietic Stem Cells/metabolism, Humans, Lipid Metabolism/physiology, Lipogenesis/physiology, Lipolysis/physiology, Neoplastic Stem Cells/metabolism, Neural Stem Cells/metabolism, Neurogenesis/physiology, Oxidative Phosphorylation, De novo lipogenesis, Cancer stem cells, Fatty acid beta-oxidation, Hematopoietic stem cells, Intestinal stem cells, Lipid metabolism, Neural stem/progenitor cells
Pubmed
Web of science
Funding(s)
University of Lausanne
Swiss National Science Foundation
Create date
27/05/2021 17:34
Last modification date
03/05/2022 6:11
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