Local auxin competition explains fragmented differentiation patterns.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_91DDD8CDC42D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Local auxin competition explains fragmented differentiation patterns.
Journal
Nature communications
Author(s)
Moret B., Marhava P., Aliaga Fandino A.C., Hardtke C.S., Ten Tusscher KHW
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
11/06/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
2965
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Trajectories of cellular ontogeny are tightly controlled and often involve feedback-regulated molecular antagonism. For example, sieve element differentiation along developing protophloem cell files of Arabidopsis roots requires two antagonistic regulators of auxin efflux. Paradoxically, loss-of-function in either regulator triggers similar, seemingly stochastic differentiation failures of individual sieve element precursors. Here we show that these patterning defects are distinct and non-random. They can be explained by auxin-dependent bistability that emerges from competition for auxin between neighboring cells. This bistability depends on the presence of an auxin influx facilitator, and can be triggered by either flux enhancement or repression. Our results uncover a hitherto overlooked aspect of auxin uptake, and highlight the contributions of local auxin influx, efflux and biosynthesis to protophloem formation. Moreover, the combined experimental-modeling approach suggests that without auxin efflux homeostasis, auxin influx interferes with coordinated differentiation.
Pubmed
Open Access
Yes
Create date
25/06/2020 15:10
Last modification date
30/04/2021 6:12
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