RNA-based gene duplication: mechanistic and evolutionary insights.

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Serval ID
serval:BIB_8F4121D7B854
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
RNA-based gene duplication: mechanistic and evolutionary insights.
Journal
Nature Reviews. Genetics
Author(s)
Kaessmann H., Vinckenbosch N., Long M.
ISSN
1471-0064 ([electronic])
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
10
Number
1
Pages
19-31
Language
english
Abstract
Gene copies that stem from the mRNAs of parental source genes have long been viewed as evolutionary dead-ends with little biological relevance. Here we review a range of recent studies that have unveiled a significant number of functional retroposed gene copies in both mammalian and some non-mammalian genomes. These studies have not only revealed previously unknown mechanisms for the emergence of new genes and their functions but have also provided fascinating general insights into molecular and evolutionary processes that have shaped genomes. For example, analyses of chromosomal gene movement patterns via RNA-based gene duplication have shed fresh light on the evolutionary origin and biology of our sex chromosomes.
Keywords
Animals, Evolution, Molecular, Gene Duplication, Genes, Duplicate, Humans, Models, Genetic, Phylogeny, RNA/genetics, RNA, Messenger/genetics, Regulatory Elements, Transcriptional/genetics, Retroelements/genetics, Sex Chromosomes
Pubmed
Web of science
Create date
18/06/2009 14:53
Last modification date
20/08/2019 14:52
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