Inflammation and TCR Signal Strength Determine the Breadth of the T Cell Response in a Bim-Dependent Manner.

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Serval ID
serval:BIB_7FE9BEB468C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inflammation and TCR Signal Strength Determine the Breadth of the T Cell Response in a Bim-Dependent Manner.
Journal
Journal of Immunology
Author(s)
Zehn D., Roepke S., Weakly K., Bevan M.J., Prlic M.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
192
Number
1
Pages
200-205
Language
english
Notes
Publication types: Journal Article
Abstract
Generating a diverse T cell memory population through vaccination is a promising strategy to overcome pathogen epitope variability and tolerance to tumor Ags. The effector and memory pool becomes broad in TCR diversity by recruiting high- and low-affinity T cells. We wanted to determine which factors dictate whether a memory T cell pool has a broad versus focused repertoire. We find that inflammation increases the magnitude of low- and high-affinity T cell responses equally well, arguing against a synergistic effect of TCR and inflammatory signals on T cell expansion. We dissect the differential effects of TCR signal strength and inflammation and demonstrate that they control effector T cell survival in a bim-dependent manner. Importantly, bim-dependent cell death is overcome with a high Ag dose in the context of an inflammatory environment. Our data define the framework for the generation of a broad T cell memory pool to inform future vaccine design.
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2014 18:23
Last modification date
20/08/2019 14:40
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