Perioperative nerve blockade: clues from the bench.

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State: Public
Version: Final published version
Serval ID
serval:BIB_7F045E04855C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Perioperative nerve blockade: clues from the bench.
Journal
Anesthesiology Research and Practice
Author(s)
Suter M.R., Siegenthaler A., Decosterd I., Ji R.R.
ISSN
1687-6970 (Electronic)
ISSN-L
1687-6962
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
2011
Pages
124898
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Peripheral and neuraxial nerve blockades are widely used in the perioperative period. Their values to diminish acute postoperative pain are established but other important outcomes such as chronic postoperative pain, or newly, cancer recurrence, or infections could also be influenced. The long-term effects of perioperative nerve blockade are still controversial. We will review current knowledge of the effects of blocking peripheral electrical activity in different animal models of pain. We will first go over the mechanisms of pain development and evaluate which types of fibers are activated after an injury. In the light of experimental results, we will propose some hypotheses explaining the mitigated results obtained in clinical studies on chronic postoperative pain. Finally, we will discuss three major disadvantages of the current blockade: the absence of blockade of myelinated fibers, the inappropriate duration of blockade, and the existence of activity-independent mechanisms.
Pubmed
Open Access
Yes
Create date
22/08/2011 9:57
Last modification date
20/08/2019 14:39
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