HENA, heterogeneous network-based data set for Alzheimer's disease.

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Version: author
License: CC BY 4.0
Serval ID
serval:BIB_7ED2F96C2385
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HENA, heterogeneous network-based data set for Alzheimer's disease.
Journal
Scientific data
Author(s)
Sügis E., Dauvillier J., Leontjeva A., Adler P., Hindie V., Moncion T., Collura V., Daudin R., Loe-Mie Y., Herault Y., Lambert J.C., Hermjakob H., Pupko T., Rain J.C., Xenarios I., Vilo J., Simonneau M., Peterson H.
ISSN
2052-4463 (Electronic)
ISSN-L
2052-4463
Publication state
Published
Issued date
14/08/2019
Peer-reviewed
Oui
Volume
6
Number
1
Pages
151
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Alzheimer's disease and other types of dementia are the top cause for disabilities in later life and various types of experiments have been performed to understand the underlying mechanisms of the disease with the aim of coming up with potential drug targets. These experiments have been carried out by scientists working in different domains such as proteomics, molecular biology, clinical diagnostics and genomics. The results of such experiments are stored in the databases designed for collecting data of similar types. However, in order to get a systematic view of the disease from these independent but complementary data sets, it is necessary to combine them. In this study we describe a heterogeneous network-based data set for Alzheimer's disease (HENA). Additionally, we demonstrate the application of state-of-the-art graph convolutional networks, i.e. deep learning methods for the analysis of such large heterogeneous biological data sets. We expect HENA to allow scientists to explore and analyze their own results in the broader context of Alzheimer's disease research.
Pubmed
Web of science
Open Access
Yes
Create date
11/09/2019 16:30
Last modification date
15/01/2021 8:10
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