Thyroid dysfunction and anaemia in a large population-based study.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_7E9D72F32D7A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thyroid dysfunction and anaemia in a large population-based study.
Journal
Clinical Endocrinology
Author(s)
M'Rabet-Bensalah K., Aubert C.E., Coslovsky M., Collet T.H., Baumgartner C., den Elzen W.P., Luben R., Angelillo-Scherrer A., Aujesky D., Khaw K.T., Rodondi N.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
84
Number
4
Pages
627-631
Language
english
Abstract
OBJECTIVE AND BACKGROUND: Anaemia and thyroid dysfunction are common and often co-occur. Current guidelines recommend the assessment of thyroid function in the work-up of anaemia, although evidence on this association is scarce.
PATIENTS AND METHODS: In the 'European Prospective Investigation of Cancer' (EPIC)-Norfolk population-based cohort, we aimed to examine the prevalence and type of anaemia (defined as haemoglobin <13 g/dl for men and <12 g/dl for women) according to different thyroid function groups.
RESULTS: The mean age of the 8791 participants was 59·4 (SD 9·1) years and 55·2% were women. Thyroid dysfunction was present in 437 (5·0%) and anaemia in 517 (5·9%) participants. After excluding 121 participants with three most common causes of anaemia (chronic kidney disease, inflammation, iron deficiency), anaemia was found in 4·7% of euthyroid participants. Compared with the euthyroid group, the prevalence of anaemia was significantly higher in overt hyperthyroidism (14·6%, P < 0·01), higher with borderline significance in overt hypothyroidism (7·7%, P = 0·05) and not increased in subclinical thyroid dysfunction (5·0% in subclinical hypothyroidism, 3·3% in subclinical hyperthyroidism). Anaemia associated with thyroid dysfunction was mainly normocytic (94·0%), and rarely macrocytic (6·0%).
CONCLUSION: The prevalence of anaemia was higher in overt hyperthyroidism, but not increased in subclinical thyroid dysfunction. Systematic measurement of thyroid-stimulating hormone in anaemic patients is likely to be useful only after excluding common causes of anaemia.
Pubmed
Web of science
Open Access
Yes
Create date
15/04/2016 16:48
Last modification date
20/08/2019 14:39
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