Compensation of Dosage-Sensitive Genes on the Chicken Z Chromosome.

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Version: Final published version
Serval ID
serval:BIB_7DFE950E8AB0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Compensation of Dosage-Sensitive Genes on the Chicken Z Chromosome.
Journal
Genome biology and evolution
Author(s)
Zimmer F., Harrison P.W., Dessimoz C., Mank J.E.
ISSN
1759-6653 (Electronic)
ISSN-L
1759-6653
Publication state
Published
Issued date
25/04/2016
Volume
8
Number
4
Pages
1233-1242
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
In many diploid species, sex determination is linked to a pair of sex chromosomes that evolved from a pair of autosomes. In these organisms, the degeneration of the sex-limited Y or W chromosome causes a reduction in gene dose in the heterogametic sex for X- or Z-linked genes. Variations in gene dose are detrimental for large chromosomal regions when they span dosage-sensitive genes, and many organisms were thought to evolve complete mechanisms of dosage compensation to mitigate this. However, the recent realization that a wide variety of organisms lack complete mechanisms of sex chromosome dosage compensation has presented a perplexing question: How do organisms with incomplete dosage compensation avoid deleterious effects of gene dose differences between the sexes? Here we use expression data from the chicken (Gallus gallus) to show that ohnologs, duplicated genes known to be dosage-sensitive, are preferentially dosage-compensated on the chicken Z chromosome. Our results indicate that even in the absence of a complete and chromosome wide dosage compensation mechanism, dosage-sensitive genes are effectively dosage compensated on the Z chromosome.

Keywords
Animals, Chickens/genetics, Dosage Compensation, Genetic, Female, Gene Dosage, Gene Duplication, Male, Sex Chromosomes/genetics, Sex Determination Processes
Pubmed
Open Access
Yes
Create date
25/04/2016 8:04
Last modification date
20/08/2019 14:39
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