Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_7DD12795F918
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.
Journal
Scientific reports
Author(s)
Rodius S., Androsova G., Götz L., Liechti R., Crespo I., Merz S., Nazarov P.V., de Klein N., Jeanty C., González-Rosa J.M., Muller A., Bernardin F., Niclou S.P., Vallar L., Mercader N., Ibberson M., Xenarios I., Azuaje F.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
31/05/2016
Peer-reviewed
Oui
Volume
6
Pages
26822
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.
Keywords
Animals, Gene Expression, Heart/physiology, Heart Injuries/physiopathology, Myocardium/metabolism, Regeneration, Transcriptome, Zebrafish, Zebrafish Proteins/genetics
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2016 16:13
Last modification date
30/04/2021 6:12
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