Free-running 5D coronary MR angiography at 1.5T using LIBRE water excitation pulses.

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Serval ID
serval:BIB_7CE167F7108B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Free-running 5D coronary MR angiography at 1.5T using LIBRE water excitation pulses.
Journal
Magnetic resonance in medicine
Author(s)
Masala N., Bastiaansen JAM, Di Sopra L., Roy C.W., Piccini D., Yerly J., Colotti R., Stuber M.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
84
Number
3
Pages
1470-1485
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To implement, optimize, and characterize lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulses for fat-suppressed fully self-gated free-running 5D cardiac MRI.
Bloch equation simulations were used to optimize LIBRE parameter settings in non-interrupted bSSFP prior to in vitro validation. Thus, optimized LIBRE pulses were subsequently applied to free-running coronary MRA in 20 human adult subjects, where resulting images were quantitatively compared to those obtained with non-fat-suppressing excitation (SP), conventional 1-2-1 water excitation (WE), and a previously published interrupted free-running (IFR) sequence. SAR and scan times were recorded. Respiratory-and-cardiac-motion-resolved images were reconstructed with XD-GRASP, and contrast ratios, coronary artery detection rate, vessel length, and vessel sharpness were computed.
The numerically optimized LIBRE parameters were successfully validated in vitro. In vivo, LIBRE had the lowest SAR and a scan time that was similar to that of WE yet 18% shorter than that of IFR. LIBRE improved blood-fat contrast when compared to SP, WE, and IFR, vessel detection relative to SP and IFR, and vessel sharpness when compared to WE and IFR (for example, for the left main and anterior descending coronary artery, 51.5% ± 10.2% [LIBRE] versus 42.1% ± 6.8% [IFR]). Vessel length measurements remained unchanged for all investigated methods.
LIBRE enabled fully self-gated non-interrupted free-running 5D bSSFP imaging of the heart at 1.5T with suppressed fat signal. Measures of image quality, vessel conspicuity, and scan time compared favorably to those obtained with the more conventional non-interrupted WE and the previously published IFR, while SAR reduction offers added flexibility.
Keywords
5D whole-heart imaging, bSSFP, coronary MRA, fat suppression, free-running framework, water excitation
Pubmed
Web of science
Create date
10/03/2020 15:32
Last modification date
18/11/2020 7:09
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